| Date | Location | Result | |
| May 27, 2021 | Charlotte, N.C. | Georgia Tech 9, Louisville 8 | Box score |
| May 25, 2021 | Charlotte, N.C. | Louisville 15, Clemson 10 | Box score |
| May 22, 2021 | Louisville, Ky. | Miami 3, Louisville 2 | Box score |
| May 21, 2021 | Louisville, Ky. | Miami 2, Louisville 0 | Box score |
| May 20, 2021 | Louisville, Ky. | Miami 6, Louisville 1 | Box score |
| May 18, 2021 | Louisville, Ky. | Louisville 8, USC Upstate 6 | Box score |
| May 16, 2021 | Chapel Hill, N.C. | North Carolina 10, Louisville 5 | Box score |
| May 15, 2021 | Chapel Hill, N.C. | North Carolina 5, Louisville 0 | Box score |
| May 14, 2021 | Chapel Hill, N.C. | North Carolina 5, Louisville 1 | Box score |
| May 08, 2021 | Louisville, Ky. | Louisville 15, Duke 6 | Box score |
| May 08, 2021 | Louisville, Ky. | Louisville 5, Duke 1 | Box score |
| May 07, 2021 | Louisville, Ky. | Duke 13, Louisville 3 | Box score |
| May 04, 2021 | Louisville, Ky. | Louisville 7, Vanderbilt 2 | Box score |
| May 02, 2021 | Clemson, S.C. | Clemson 15, Louisville 5 | Box score |
| May 01, 2021 | Clemson,S.C. | Clemson 5, Louisville 4 | Box score |
| Apr 30, 2021 | Clemson, S.C. | Clemson 11, Louisville 3 | Box score |
| Apr 20, 2021 | Lexington, Ky. | Louisville 12, Kentucky 5 | Box score |
| Apr 18, 2021 | Charlottesville, Va. | Louisville 8, Virginia 2 | Box score |
| Apr 17, 2021 | Charlottesville, Va. | Louisville 9, Virginia 5 | Box score |
| Apr 16, 2021 | Charlottesville, Va. | Virginia 8, Louisville 7 | Box score |
| Apr 11, 2021 | Louisville, Ky. | Louisville 11, Florida State 4 | Box score |
| Apr 10, 2021 | Louisville, Ky. | Florida State 8, Louisville 5 | Box score |
| Apr 09, 2021 | Louisville, Ky. | Louisville 4, Florida State 3 | Box score |
| Apr 06, 2021 | Louisville, Ky. | Kentucky 11, Louisville 7 | Box score |
| Apr 04, 2021 | Louisville, Ky. | Wake Forest 6, Louisville 3 | Box score |
| Apr 03, 2021 | Louisville, Ky. | Louisville 9, Wake Forest 7 | Box score |
| Apr 02, 2021 | Louisville, Ky. | Louisville 5, Wake Forest 3 | Box score |
| Mar 30, 2021 | Cincinnati, OH | Cincinnati 13, Louisville 12 | Box score |
| Mar 27, 2021 | Notre Dame, IN | Notre Dame 5, Louisville 3 | Box score |
| Mar 26, 2021 | Notre Dame, IN | Louisville 7, Notre Dame 4 | Box score |
| Mar 23, 2021 | Louisville, Ky. | Louisville 13, Western Kentucky 6 | Box score |
| Mar 21, 2021 | Raleigh, N.C. | Louisville 8, NC State 3 | Box score |
| Mar 20, 2021 | Raleigh, N.C. | Louisville 6, NC State 3 | Box score |
| Mar 19, 2021 | Raleigh, N.C. | Louisville 13, NC State 1 | Box score |
| Mar 16, 2021 | Richmond, Ky. | Eastern Kentucky 6, Louisville 3 | Box score |
| Mar 14, 2021 | Louisville, Ky. | Louisville 8, Boston College 6 | Box score |
| Mar 13, 2021 | Louisville, Ky. | Louisville 5, Boston College 0 | Box score |
| Mar 12, 2021 | Louisville, Ky. | Louisville 7, Boston College 3 | Box score |
| Mar 09, 2021 | Louisville, Ky. | Louisville 8, Murray State 3 | Box score |
| Mar 07, 2021 | Atlanta, Ga. | Georgia Tech 13, Louisville 9 | Box score |
| Mar 06, 2021 | Atlanta, Ga. | Georgia Tech 19, Louisville 6 | Box score |
| Mar 05, 2021 | Atlanta, Ga. | Louisville 13, Georgia Tech 6 | Box score |
| Mar 02, 2021 | Louisville, Ky. | Morehead State 5, Louisville 2 | Box score |
| Feb 27, 2021 | Louisville, Ky. | Louisville 9, Western Illinois 4 | Box score |
| Feb 27, 2021 | Louisville, Ky. | Louisville 4, Western Illinois 1 | Box score |
| Feb 26, 2021 | Louisville, Ky. | Western Illinois 8, Louisville 3 | Box score |
| Feb 23, 2021 | Louisville, Ky. | Louisville 6, Eastern Kentucky 2 | Box score |
| Feb 21, 2021 | Louisville, Ky. | Louisville 8, Bellarmine 3 | Box score |
| Feb 21, 2021 | Louisville, Ky. | Louisville 13, Bellarmine 1 | Box score |
| Feb 20, 2021 | Louisville, Ky. | Louisville 5, Bellarmine 1 | Box score |