| Date | Location | Result | |
| 03/09/22 | Brooklyn, NY | Virginia 51, Louisville 50 | Box score |
| 03/08/22 | Brooklyn, NY | Louisville 84, Georgia Tech 74 | Box score |
| 03/05/22 | Louisville, KY | Virginia 71, Louisville 61 | Box score |
| 03/01/22 | Blacksburg, VA | Virginia Tech 75, Louisville 43 | Box score |
| 02/26/22 | Winston-Salem, NC | Wake Forest 99, Louisville 77 | Box score |
| 02/21/22 | Chapel Hill, NC | North Carolina 70, Louisville 63 | Box score |
| 02/19/22 | Louisville, KY | Louisville 70, Clemson 61 | Box score |
| 02/16/22 | Louisville, KY | Miami (FL) 70, Louisville 63 | Box score |
| 02/09/22 | Notre Dame, IN | Notre Dame 63, Louisville 57 | Box score |
| 02/05/22 | Syracuse, NY | Syracuse 92, Louisville 69 | Box score |
| 02/01/22 | Louisville, KY | North Carolina 90, Louisville 83 (OT) | Box score |
| 01/29/22 | Louisville, KY | Duke 74, Louisville 65 | Box score |
| 01/24/22 | Charlottesville, VA | Virginia 64, Louisville 52 | Box score |
| 01/22/22 | Louisville, KY | Notre Dame 82, Louisville 70 | Box score |
| 01/19/22 | Louisville, KY | Louisville 67, Boston College 54 | Box score |
| 01/15/22 | Pittsburgh, PA | Pittsburgh 65, Louisville 53 | Box score |
| 01/12/22 | Louisville, KY | NC State 79, Louisville 63 | Box score |
| 01/08/22 | Tallahassee, FL | Florida St. 79, Louisville 70 | Box score |
| 01/05/22 | Louisville, KY | Louisville 75, Pittsburgh 72 | Box score |
| 01/02/22 | Atlanta, GA | Louisville 67, Georgia Tech 64 | Box score |
| 12/29/21 | Louisville, KY | Louisville 73, Wake Forest 69 | Box score |
| 12/18/21 | Bowling Green, KY | Western Ky. 82, Louisville 72 | Box score |
| 12/14/21 | Louisville, KY | Louisville 86, Southeastern La. 60 | Box score |
| 12/10/21 | Louisville, KY | DePaul 62, Louisville 55 | Box score |
| 12/04/21 | Raleigh, NC | Louisville 73, NC State 68 | Box score |
| 12/01/21 | East Lansing, MI | Michigan St. 73, Louisville 64 | Box score |
| 11/27/21 | Nassau, Bahamas | Louisville 63, Maryland 55 | Box score |
| 11/25/21 | Nassau, Bahamas | Louisville 72, Mississippi St. 58 | Box score |
| 11/20/21 | Louisville, KY | Louisville 73, Detroit Mercy 67 | Box score |
| 11/15/21 | Louisville, KY | Louisville 77, Navy 60 | Box score |
| 11/12/21 | Louisville, KY | Furman 80, Louisville 72 (OT) | Box score |
| 11/09/21 | Louisville, KY | Louisville 72, Southern U. 60 | Box score |