| Date | Location | Result | |
| Dec 12, 2020 | Louisville, KY | Louisville 45, Wake Forest 21 | Box score |
| Nov 28, 2020 | Chestnut Hill, Mass. | Boston College 34, Louisville 27 | Box score |
| Nov 20, 2020 | Louisville, KY | Louisville 30, Syracuse 0 | Box score |
| Nov 14, 2020 | Charlottesville, Va. | Virginia 31, Louisville 17 | Box score |
| Oct 31, 2020 | Louisville, KY | Virginia Tech 42, Louisville 35 | Box score |
| Oct 24, 2020 | Louisville, KY | Louisville 48, Florida State 16 | Box score |
| Oct 17, 2020 | Notre Dame, | Notre Dame 12, Louisville 7 | Box score |
| Oct 09, 2020 | Atlanta, Ga. | Georgia Tech 46, Louisville 27 | Box score |
| Sep 26, 2020 | Pittsburgh, PA | Pitt 23, Louisville 20 | Box score |
| Sep 19, 2020 | Louisville, KY | Miami 47, Louisville 34 | Box score |
| Sep 12, 2020 | Louisville, KY | Louisville 35, Western Kentucky 21 | Box score |