| Date | Location | Result | |
| Dec 28, 2021 | Dallas, Texas | Air Force 31, Louisville 28 | Box score |
| Nov 27, 2021 | Louisville, Kentucky | Kentucky 52, Louisville 21 | Box score |
| Nov 18, 2021 | Durham, North Caroli | Louisville 62, Duke 22 | Box score |
| Nov 13, 2021 | Louisville, Kentucky | Louisville 41, Syracuse 3 | Box score |
| Nov 06, 2021 | Louisville, Kentucky | Clemson 30, Louisville 24 | Box score |
| Oct 30, 2021 | Raleigh, North Carol | NC State 28, Louisville 13 | Box score |
| Oct 23, 2021 | Louisville, Kentucky | Louisville 28, Boston College 14 | Box score |
| Oct 09, 2021 | Louisville, Kentucky | Virginia 34, Louisville 33 | Box score |
| Oct 02, 2021 | Winston-Salem, North | Wake Forest 37, Louisville 34 | Box score |
| Sep 25, 2021 | Tallahassee, Florida | Louisville 31, Florida St. 23 | Box score |
| Sep 17, 2021 | Louisville, Kentucky | Louisville 42, UCF 35 | Box score |
| Sep 11, 2021 | Louisville, Kentucky | Louisville 30, Eastern Ky. 3 | Box score |
| Sep 06, 2021 | Atlanta, Georgia | Ole Miss 43, Louisville 24 | Box score |