| Date | Location | Result | |
| 03/10/21 | Greensboro, NC | Duke 70, Louisville 56 | Box score |
| 03/06/21 | Louisville, KY | Virginia 68, Louisville 58 | Box score |
| 02/27/21 | Durham, NC | Louisville 80, Duke 73 (OT) | Box score |
| 02/23/21 | Louisville, KY | Louisville 69, Notre Dame 57 | Box score |
| 02/20/21 | Chapel Hill, NC | North Carolina 99, Louisville 54 | Box score |
| 02/01/21 | Louisville, KY | Louisville 74, Georgia Tech 58 | Box score |
| 01/27/21 | Clemson, SC | Clemson 54, Louisville 50 | Box score |
| 01/23/21 | Louisville, KY | Louisville 70, Duke 65 | Box score |
| 01/18/21 | Louisville, KY | Florida St. 78, Louisville 65 | Box score |
| 01/16/21 | Coral Gables, FL | Miami (FL) 78, Louisville 72 | Box score |
| 01/13/21 | Winston-Salem, NC | Louisville 77, Wake Forest 65 | Box score |
| 01/06/21 | Louisville, KY | Louisville 73, Virginia Tech 71 | Box score |
| 01/02/21 | Boston, MA | Louisville 76, Boston College 64 | Box score |
| 12/26/20 | Louisville, KY | Louisville 62, Kentucky 59 | Box score |
| 12/22/20 | Pittsburgh, PA | Louisville 64, Pittsburgh 54 | Box score |
| 12/19/20 | Madison, WI | Wisconsin 85, Louisville 48 | Box score |
| 12/01/20 | Louisville, KY | Louisville 75, Western Ky. 54 | Box score |
| 11/29/20 | Louisville, KY | Louisville 86, Prairie View 64 | Box score |
| 11/27/20 | Louisville, KY | Louisville 71, Seton Hall 70 | Box score |
| 11/25/20 | Louisville, KY | Louisville 79, Evansville 44 | Box score |