| Date | Location | Result | |
| Dec 30, 2017 | JACKSONVILLE, FL | MISS. STATE 31, LOUISVILLE 27 | Box score |
| Nov 25, 2017 | LEXINGTON, KY | LOUISVILLE 44, KENTUCKY 17 | Box score |
| Nov 18, 2017 | LOUISVILLE, KY | LOUISVILLE 56, SYRACUSE 10 | Box score |
| Nov 11, 2017 | LOUISVILLE, KY | LOUISVILLE 38, VIRGINIA 21 | Box score |
| Oct 28, 2017 | WINSTON-SALEM, NC | WAKE FOREST 42, LOUISVILLE 32 | Box score |
| Oct 21, 2017 | TALLAHASSEE, FL | LOUISVILLE 31, FLORIDA STATE 28 | Box score |
| Oct 14, 2017 | LOUISVILLE, KY | BOSTON COLLEGE 45, LOUISVILLE 42 | Box score |
| Oct 05, 2017 | RALEIGH, NC | NC STATE 39, LOUISVILLE 25 | Box score |
| Sep 30, 2017 | LOUISVILLE, KY | LOUISVILLE 55, MURRAY STATE 10 | Box score |
| Sep 23, 2017 | LOUISVILLE, KY | LOUISVILLE 42, KENT STATE 3 | Box score |
| Sep 16, 2017 | LOUISVILLE, KY | CLEMSON 47, LOUISVILLE 21 | Box score |
| Sep 09, 2017 | CHAPEL HILL, NC | LOUISVILLE 47, NORTH CAROLINA 35 | Box score |
| Sep 02, 2017 | INDIANAPOLIS, IN | LOUISVILLE 35, PURDUE 28 | Box score |