| Date | Location | Result | |
| 11/18/21 | Louisville, UNITED S | Bowling Green 1, Louisville 0 | |
| 11/07/21 | Louisville, UNITED S | Notre Dame 0, Louisville 0 (3OT) | |
| 10/29/21 | Clemson, UNITED STAT | Clemson 5, Louisville 1 | |
| 10/22/21 | Louisville, UNITED S | Louisville 2, NC State 1 | |
| 10/19/21 | Louisville, UNITED S | Oakland 2, Louisville 1 | |
| 10/15/21 | Louisville, UNITED S | Louisville 2, North Carolina 0 | |
| 10/12/21 | Louisville, UNITED S | Louisville 5, Eastern Ill. 0 | |
| 10/08/21 | Blacksburg, Va., Uni | Virginia Tech 4, Louisville 2 | |
| 10/01/21 | Durham, UNITED STATE | Duke 3, Louisville 1 | |
| 09/28/21 | Louisville, UNITED S | Louisville 7, Western Ill. 1 | |
| 09/24/21 | Louisville, UNITED S | Louisville 2, Boston College 0 | |
| 09/21/21 | Louisville, UNITED S | Louisville 4, Northern Ky. 0 | |
| 09/17/21 | Syracuse, UNITED STA | Louisville 5, Syracuse 4 (2OT) | |
| 09/10/21 | Louisville, UNITED S | Louisville 3, Wake Forest 0 | |
| 09/07/21 | Louisville, UNITED S | Kentucky 3, Louisville 1 | |
| 09/03/21 | Louisville, UNITED S | Louisville 1, Bellarmine 0 (2OT) | |
| 08/30/21 | Louisville, UNITED S | Louisville 2, Evansville 1 | |
| 08/26/21 | St. Louis, UNITED ST | Saint Louis 2, Louisville 1 (2OT) |